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Ailing Novak Djokovic suffered his earliest Grand Slam exit in 20 years on Sunday, falling in five brutal sets to Mariano Navone in the first round of the US Open.<\/strong><\/p>\n The 48th-ranked Argentine\u2019s 7-6 (7\/5), 5-7, 4-6, 6-2, 6-1 victory ended Djokovic\u2019s latest bid for a record 25th Grand Slam title, the monumental achievement looking ever less likely for the 39-year-old.<\/p>\n It also ended his run of 78 Grand Slam first-round victories, a streak stretching all the way back to Djokovic\u2019s 2006 loss to Paul Goldstein at the 2006 Australian Open.<\/p>\n \u201cI think it was obvious that it was an awful feeling on the court for me,\u201d said Djokovic, who vomited several times and battled late-match cramps.<\/p>\n \u201cIt\u2019s something that I\u2019ve been carrying, unfortunately, pretty much every match this year. Vomiting, throwing up, a serious issue there. Then my whole body starts to collapse, basically cramping and pain.<\/p>\n \u201cThe back just gave up in the end and shoulder, I couldn\u2019t close it out.\u201d<\/p>\n Djokovic, who took medication during the match, appeared to have finally taken control when he broke Navone for a 2-1 lead in the fourth set with a vintage backhand winner down the line.<\/p>\n But Navone won the next five games, raising his arms in celebration after fighting off two break points for a 5-2 lead and breaking Djokovic again to force the fifth.<\/p>\n Djokovic took a medical timeout before the final set, receiving massage on his spine and more medication.<\/p>\n But Navone jumped to a 3-0 lead in the decisive set and despite the urging of fans there was no road back for the Serb as his opponent dropped just one point on his own serve as he sprinted to the finish line.<\/p>\n Djokovic, a four-time US Open champion, had never lost before the third round in Flushing Meadows, but he\u2019d shown signs of frailty in his only tune-up, struggling physically in losing his opening match in Cincinnati.<\/p>\n Even as he grabbed a 4-1 lead in the first set Djokovic was clearly not himself. Every rally left him gasping, and he finally surrendered the set with a dismal forehand into the net.<\/p>\n In a tense second set Djokovic missed break chances in the third and fifth games before breaking Navone at love for a 6-5 lead and holding at love to level the match at one set apiece.<\/p>\n The third set was more of the same, Djokovic seizing the crucial break in the ninth game and fending off a break point in the next for a two sets to one lead.<\/p>\n That put paid to any thought he\u2019d had of retiring.<\/p>\n \u201cI have, I have,\u201d he said when asked if he\u2019d thought of throwing in the towel. \u201cBut then I won a set and then the third. I didn\u2019t want to give up.\u201d<\/p>\n Determination wasn\u2019t enough. He was 2-1 up in the fourth set when the cramps struck and lost eight games in a row.<\/p>\n Pegula, Medvedev advance<\/strong><\/p>\n Djokovic departed to cheers nearly 12 hours after world number three Jessica Pegula conquered her first-round nerves to dispatch Elena-Gabriela Ruse 6-3, 6-2.<\/p>\n Pegula broke Romania\u2019s Ruse twice in each set, but it was less straightforward than the score indicated as the 32-year-old veteran felt the weight of opening the action on the cavernous Arthur Ashe Stadium.<\/p>\n \u201cOh yeah, I was so nervous today, always the first round of a slam,\u201d said Pegula, who has won two titles this year and reached three other finals.<\/p>\n Her consistent high level means she could capture not only a first Grand Slam title but also the world number one ranking.<\/p>\n Seventh-seeded former champion Daniil Medvedev also advanced with a serene 6-4, 6-2, 6-4 victory over France\u2019s Hugo Gaston.<\/p>\n It was a far cry from Medvedev\u2019s meltdown in a first-round loss last year and a heartening performance in another year of mixed results for the Russian.<\/p>\n \u201cI felt like I did everything I wanted to do well,\u201d he said.<\/p>\n But there was plenty of drama elsewhere.<\/p>\n Dino Prizmic saved two match points in a 2-6, 6-3, 6-3, 5-7, 7-5 victory over Aleksandr Shevchenko.<\/p>\n And Spaniard Jaume Munar needed nearly five hours to secure a 6-7 (5\/7), 3-6, 6-1, 7-6 (7\/4), 7-5 victory over Frenchman Terence Atmane.<\/p>\n<\/div>\n