NFL Week 2 betting: Odds, lines and totals for every game
Sep 12, 2025, 12:32 PM ET Week 2 gets started with a matchup between the Washington Commanders and Green Bay Packers, two playoff teams from last season, at Lambeau Field on Thursday night. Both teams won their Week 1 games. There are several compelling matchups Sunday, including the Chicago Bears visiting the Detroit Lions (-4.5)…
Week 2 gets started with a matchup between the Washington Commanders and Green Bay Packers, two playoff teams from last season, at Lambeau Field on Thursday night. Both teams won their Week 1 games.
There are several compelling matchups Sunday, including the Chicago Bears visiting the Detroit Lions (-4.5) in early window and the Atlanta Falcons visiting the Minnesota Vikings (-4.5) on “Sunday Night Football,” but Week 2’s biggest game is a Super Bowl rematch between the Philadelphia Eagles (-1.5)and Kansas City Chiefs at Arrowhead Stadium.
The week wraps up with a “Monday Night Football” doubleheader, with the Houston Texans (-2.5) histing the Tampa Bay Buccaneers (7 p.m. ET on ABC/ESPN) followed by the Los Angeles Chargers (-3.5) visiting the Las Vegas Raiders (10 p.m. ET on ESPN).
Here’s a look at the opening odds for every Week 2 game.
For the most current odds, visit ESPN BET.
Jump to:
SF-NO | JAX-CIN | BUF-NYJ
NYG-DAL | NE-MIA | CHI-DET | LAR-TEN
CLE-BAL | SEA-PIT | CAR-ARI | DEN-IND
PHI-KC | ATL-MIN | TB-HOU | LAC-LV
San Francisco 49ers -3.5 vs. New Orleans Saints
Sunday, 1 p.m., FOX
Line movement: Opened 49ers -7.5
Money Line: 49ers (-175); Saints (+150)
Total: 40.5; Opened: 43.5
FPI favorite: 49ers by 0.9 with a 52% probability to win the game outright
Jacksonville Jaguars vs. Cincinnati Bengals -3.5
Sunday, 1 p.m., CBS
Money Line: Jaguars (+165); Bengals (-195)
Total: 48.5; Opened: 49.5
FPI favorite: Bengals by 4 with a 60.07% probability to win the game outright
Buffalo Bills -6.5 vs. New York Jets
Sunday, 1 p.m., CBS
Money Line: Bills (-320); Jets (+260)
Total: 47.5; Opened: 45.5
FPI favorite: Bills by 6.1 with a 64.67% probability to win the game outright
New York Giants vs. Dallas Cowboys -5.5
Sunday, 1 p.m., FOX
Line movement: Opened Cowboys -3.5
Money Line: Giants (+210); Cowboys (-250)
Total: 44.5; Opened: 45.5
FPI favorite: Cowboys by 6.6 with a 66% probability to win the game outright
New England Patriots vs. Miami Dolphins -1.5
Sunday, 1 p.m., CBS
Money Line: Patriots (+110); Dolphins (-130)
Total: 42.5; Opened: 44.5
FPI favorite: Dolphins by 1.1 with a 53.07% probability to win the game outright
Chicago Bears vs. Detroit Lions -6.5
Sunday, 1 p.m., FOX
Money Line: Bears (+240); Lions (-290)
Total: 46.5; Opened: 47.5
FPI favorite: Lions by 4.6 with a 62% probability to win the game outright
Los Angeles Rams -5.5 vs. Tennessee Titans
Sunday, 1 p.m., CBS
Money Line: Rams (-260); Titans (+215)
Total: 41.5; Opened: 42.5
FPI favorite: Rams by 6.7 with a 66.93% probability to win the game outright
Cleveland Browns vs. Baltimore Ravens -11.5
Sunday, 1 p.m., CBS
Money Line: Browns (+550); Ravens (-900)
Total: 44.5; Opened: 45.5
FPI favorite: Ravens by 12.9 with a 79.73% probability to win the game outright
Seattle Seahawks vs. Pittsburgh Steelers -3.5
Sunday, 1 p.m., FOX
Money Line: Seahawks (+140); Steelers (-165)
Total: 39.5; Opened: 40.5
FPI favorite: Steelers by 4.6 with a 61.2% probability to win the game outright
Carolina Panthers vs. Arizona Cardinals -6.5
Sunday, 4:05 p.m., CBS
Money Line: Panthers (+260); Cardinals (-320)
Total: 44.5; Opened: 45.5
FPI favorite: Cardinals by 6.2 with a 65.8% probability to win the game outright
Denver Broncos -1.5 vs. Indianapolis Colts
Sunday, 4:05 p.m., CBS
Money Line: Broncos (-120); Colts (+100)
Total: 43.5; Opened: 44.5
FPI favorite: Colts by 0.7 with a 51.4% probability to win the game outright
Philadelphia Eagles -1.5 vs. Kansas City Chiefs
Sunday, 4:25 p.m., FOX
Money Line: Eagles (-120); Chiefs (+100)
Total: 46.5; Opened: 45.5
FPI favorite: Chiefs by 1 with a 52.47% probability to win the game outright
Atlanta Falcons vs. Minnesota Vikings -3.5
Sunday, 8:20 p.m., NBC
Money Line: Falcons (+145); Vikings (-170)
Total: 44.5; Opened: 45.5
FPI favorite: Vikings by 5.7 with a 64.6% probability to win the game outright
Tampa Bay Buccaneers vs. Houston Texans -2.5
Monday, 7 p.m., ABC, ESPN
Money Line: Buccaneers (+120); Texans (-140)
Total: 42.5; Opened: 45.5
FPI favorite: Buccaneers by 0 with a 50.13% probability to win the game outright
Los Angeles Chargers -3.5 vs. Las Vegas Raiders
Monday, 10 p.m., ESPN
Money Line: Chargers (-190); Raiders (+160)
Total: 45.5; Opened: 44.5
FPI favorite: Chargers by 3.7 with a 59.67% probability to win the game outright
