NFL Week 4 betting: Odds, lines and totals for every game

Sep 22, 2025, 12:58 PM ET Week 4 gets underway with a matchup of NFC West rivals when the Arizona Cardinals host the Seattle Seahawks on “Thursday Night Football.” Sunday night features Micah Parsons and the Green Bay Packers hitting the road to take on the Dallas Cowboys. The week wraps up with a “Monday…

Sep 22, 2025, 12:58 PM ET

Week 4 gets underway with a matchup of NFC West rivals when the Arizona Cardinals host the Seattle Seahawks on “Thursday Night Football.”

Sunday night features Micah Parsons and the Green Bay Packers hitting the road to take on the Dallas Cowboys.

The week wraps up with a “Monday Night Football” doubleheader as the New York Jets visit the Miami Dolphins (7:15 ET on ESPN) and the Denver Broncos host the Cincinnati Bengals (8:15 on ABC).

Here’s a look at the odds for every Week 4 game.

Odds as of publication time. For the most current odds, visit ESPN BET.

Jump to:
SEA-ARI | MIN-PIT | NO-BUF | LAC-NYG
WSH-ATL | PHI-TB | CLE-DET | CAR-NE
TEN-HOU | JAX-SF | IND-LAR | CHI-LV
BAL-KC | GB-DAL | NYJ-MIA | CIN-DEN

end rule

seaariSeattle Seahawks vs. Arizona Cardinals -1.5
Thursday, 8:15 p.m., Prime Video

Money line: Seahawks (-105); Cardinals (-115)
Total: 43.5; Opened: 44.5
FPI favorite: Cardinals by 0.8 with a 52.47% probability to win outright

minpitMinnesota Vikings -2.5 vs. Pittsburgh Steelers
Sunday, 9:30 a.m., NFL Net, NFL+

Money line: Vikings (-150); Steelers (+130)
Total: 40.5; Opened: 41.5
FPI favorite: Vikings by 3.1 with a 57.18% probability to win outright

nobufNew Orleans Saints vs. Buffalo Bills -15.5
Sunday, 1 p.m., CBS

Money line: Saints (+900); Bills (-1800)
Total: 47.5; Opened: 48.5
FPI favorite: Bills by 13.3 with a 79.67% probability to win outright

lacnygLos Angeles Chargers -6.5 vs. New York Giants
Sunday, 1 p.m., CBS

Money line: Chargers (-280); Giants (+230)
Total: 44.5; Opened: 45.5
FPI favorite: Chargers by 6.8 with a 67.8% probability to win outright

wshatlWashington Commanders -2.5 vs. Atlanta Falcons
Sunday, 1 p.m., CBS

Money line: Commanders (-145); Falcons (+125)
Total: 44.5; Opened: 46.5
FPI favorite: Commanders by 3.8 with a 59.33% probability to win outright

phitbPhiladelphia Eagles -3.5 vs. Tampa Bay Buccaneers
Sunday, 1 p.m., Fox

Money line: Eagles (-170); Buccaneers (+145)
Total: 44.5; Opened: 45.5
FPI favorite: Eagles by 1.7 with a 54.6% probability to win outright

cledetCleveland Browns vs. Detroit Lions -8.5
Sunday, 1 p.m., Fox

Money line: Browns (+360); Lions (-500)
Total: 45.5; Opened: 45.5
FPI favorite: Lions by 10.8 with a 75.73% probability to win outright

carneCarolina Panthers vs. New England Patriots -5.5
Sunday, 1 p.m., Fox

Money line: Panthers (+195); Patriots (-230)
Total: 43.5; Opened: 44.5
FPI favorite: Patriots by 2.4 with a 56.07% probability to win outright

tenhouTennessee Titans vs. Houston Texans -6.5
Sunday, 1 p.m., CBS

Money line: Titans (+280); Texans (-360)
Total: 39.5; Opened: 39.5
FPI favorite: Texans by 7.9 with a 69.67% probability to win outright

sfJacksonville Jaguars vs. San Francisco 49ers -3.5
Sunday, 4:05 p.m., Fox

Money line: Jaguars (+150); 49ers (-175)
Total: 46.5; Opened: 45.5
FPI favorite: 49ers by 0.3 with a 50.07% probability to win outright

indlarIndianapolis Colts vs. Los Angeles Rams -3.5
Sunday, 4:05 p.m., Fox

Money line: Colts (+160); Rams (-190)
Total: 48.5; Opened: 48.5
FPI favorite: Rams by 2.6 with a 57.2% probability to win outright

chilvChicago Bears vs. Las Vegas Raiders -1.5
Sunday, 4:25 p.m., CBS

Line movement: Opened Bears -1.5

Money line: Bears (-105); Raiders (-115)
Total: 47.5; Opened: 47.5
FPI favorite: Bears by 0.6 with a 51.6% probability to win outright

balkcBaltimore Ravens -2.5 vs. Kansas City Chiefs
Sunday, 4:25 p.m., CBS

Money line: Ravens (-150); Chiefs (+130)
Total: 48.5; Opened: 48.5
FPI favorite: Ravens by 0.6 with a 50.98% probability to win outright

gbdalGreen Bay Packers -6.5 vs. Dallas Cowboys
Sunday, 8:20 p.m., NBC

Money line: Packers (-275); Cowboys (+225)
Total: 47.5; Opened: 48.5
FPI favorite: Packers by 3.5 with a 58.8% probability to win outright

nyjmiaNew York Jets vs. Miami Dolphins -2.5
Monday, 7:15 p.m., ESPN

Money line: Jets (+120); Dolphins (-140)
Total: 45.5; Opened: 44.5
FPI favorite: Dolphins by 2.3 with a 56.8% probability to win outright

cindenCincinnati Bengals vs. Denver Broncos -7.5
Monday, 8:15 p.m., ABC

Money line: Bengals (+290); Broncos (-380)
Total: 44.5; Opened: 44.5
FPI favorite: Broncos by 8.8 with a 72% probability to win outright

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